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The in vitro oxidative metabolic stability of C-021 (Compound 1b) is evaluated by measuring the rate of drug consumption in human liver microsomes (HML)
6 and 65 ± 2
Audiol Neurootol
ACT-335827 (100 mg/kg) reduced the tachycardic and pressor by 48% and 32%
3'-Fluorobenzylspiperone maleate Catalog No.:M23267-C The in vitro oxidative metabolicProduct information CAS Number: 1135278 61 3 Molecular Weight: 619. 66 Formula: C34H35F2N3O6 Chemical Name: (2Z) but 2 enedioic acid; 8 [4 (4 fluorophenyl) 4 oxobutyl] 3 [(3 fluorophenyl)methyl] 1 phenyl 1,3,8 triazaspiro[4. 5]decan 4 one Smiles: OC(=O) C=C\C(O)=O. O=C1N(CC2C=C(F)C=CC=2)CN(C2C=CC=CC=2)C21CCN(CCCC(=O)C1C=CC(F)=CC=1)CC2 InChiKey: JURUFADWVGXLOY BTJKTKAUSA N InChi: InChI=1S C30H31F2N3O2. C4H4O4 c31 25 13 11 24(12 14 25)28(36)10 5 17 33